C Reactive Protein Vitamin C ~ Rocio Health Prime

C Reactive Protein Vitamin C

Clinical Trial

doi: 10.1016/j.freeradbiomed.2008.09.030. Epub 2008 Oct 10.

Vitamin C treatment reduces elevated C-reactive protein

Affiliations

PMID: 18952164
PMCID: PMC2631578
DOI: 10.1016/j.freeradbiomed.2008.09.030

Free PMC article

Clinical Trial

Vitamin C treatment reduces elevated C-reactive protein

Gladys Block et al. Free Radic Biol Med. 2009 .

Free PMC article

Abstract

Plasma C-reactive protein (CRP) is an inflammatory biomarker that predicts cardiovascular disease. Lowering elevated CRP with statins has reduced the incidence of cardiovascular disease. We investigated whether vitamin C or E could reduce CRP. Healthy nonsmokers (N=396) were randomized to three groups, 1000 mg/day vitamin C, 800 IU/day vitamin E, or placebo, for 2 months. Median baseline CRP was low, 0.85 mg/L. No treatment effect was seen when all participants were included. However, a significant interaction was found, indicating that treatment effect depends on baseline CRP concentration. Among participants with CRP indicative of elevated cardiovascular risk (> or =1.0 mg/L), vitamin C reduced the median CRP by 25.3% vs placebo (p=0.02) (median reduction in the vitamin C group, 0.25 mg/L, 16.7%). These effects are similar to those of statins. The vitamin E effect was not significant. In summary, treatment with vitamin C but not vitamin E significantly reduced CRP among individuals with CRP > or =1.0 mg/L. Among the obese, 75% had CRP > or =1.0 mg/L. Research is needed to determine whether reducing this inflammatory biomarker with vitamin C could reduce diseases associated with obesity. But research on clinical benefits of antioxidants should limit participants to persons with elevations in the target biomarkers.

Figures

**Figure 1**
Flow.diagram of participant progress through the study

**Figure 2**
Vertical axis, CRP mg/L. Two plots are shown, CRP distribution in those with CRP < 10 mg/L, and in those with CRP ≥ 10 mg/L. The boxes indicate 25th, 50th and 75th percentile, and the tails on the boxes represent minimum and maximum.

**Figure 3**
Percent with CRP ≥ 1.0 mg/L at baseline, by BMI status. P=0.0001 for difference in groups.

Cited by 32 articles

Current Status of Primary, Secondary, and Tertiary Prevention of Coronary Artery Disease.

Prasad K. Prasad K. Int J Angiol. 2021 Aug 25;30(3):177-186. doi: 10.1055/s-0041-1731273. eCollection 2021 Sep. Int J Angiol. 2021. PMID: 34776817 Review.
The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19.

Cerullo G, Negro M, Parimbelli M, Pecoraro M, Perna S, Liguori G, Rondanelli M, Cena H, D'Antona G. Cerullo G, et al. Front Immunol. 2020 Oct 28;11:574029. doi: 10.3389/fimmu.2020.574029. eCollection 2020. Front Immunol. 2020. PMID: 33193359 Free PMC article. Review.
Ascorbate attenuates cycling exercise-induced neuromuscular fatigue but fails to improve exertional dyspnea and exercise tolerance in COPD.

Hureau TJ, Weavil JC, Sidhu SK, Thurston TS, Reese VR, Zhao J, Nelson AD, Birgenheier NM, Richardson RS, Amann M. Hureau TJ, et al. J Appl Physiol (1985). 2021 Jan 1;130(1):69-79. doi: 10.1152/japplphysiol.00611.2020. Epub 2020 Nov 5. J Appl Physiol (1985). 2021. PMID: 33151775
The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials.

Asbaghi O, Sadeghian M, Nazarian B, Sarreshtedari M, Mozaffari-Khosravi H, Maleki V, Alizadeh M, Shokri A, Sadeghi O. Asbaghi O, et al. Sci Rep. 2020 Oct 14;10(1):17234. doi: 10.1038/s41598-020-73741-6. Sci Rep. 2020. PMID: 33057114 Free PMC article.

Rocio Health Prime